Autoreactive CD4+ T cells, including IFNγ-secreting T helper (Th) 1, IFNγ/IL‐17-secreting Th17, or IFNγ/GM‐CSF-secreting cells [2, 4–6], play an important role in MS, which is supported by data from the experimental autoimmune encephalomyelitis (EAE) mouse models [7]. The gene discussed is IFNG; the disease is experimental autoimmune encephalomyelitis.