The SFM-DR is mediated by CAF-produced cytokines, chemokines, growth factors, exosomes, and desmoplastic reactions, which protect cancer cells against drug-induced apoptosis, while the CAM-DR is mediated by the adhesion of cancer cell integrins to stromal fibroblasts or to components of the ECM, such as fibronectin, collagen, and laminin. This evidence concerns the gene FN1 and cancer.