In a xenograft model of NSCLC, integrin α11 is reported to regulate the expression of CAF-derived lysyl oxidase like-1 (LOXL1), a matrix cross-linking enzyme, hence supporting tumor growth and immunoresistance through collagen matrix remodeling and collagen fiber alignment both in vitro and in vivo [115]. Here, LOXL1 is linked to non-small cell lung carcinoma.