LAMB2 and cancer: The SFM-DR is mediated by CAF-produced cytokines, chemokines, growth factors, exosomes, and desmoplastic reactions, which protect cancer cells against drug-induced apoptosis, while the CAM-DR is mediated by the adhesion of cancer cell integrins to stromal fibroblasts or to components of the ECM, such as fibronectin, collagen, and laminin.