On the one hand, with the help of the paracrine regulatory factors including cytokines (TGF-β, TNF-α, IL-1, etc.), chemokines, and growth factors secreted by CAFs and cancer cells, CAFs facilitate in architecting a milieu feasible for tumor angiogenesis, metastasis, and therapeutic resistance, hence favoring tumor growth [23]. Here, TGFB1 is linked to cancer.