LATS2 and breast cancer: Besides, CAF-derived exosomal miR-92 could downregulate large tumor suppressor kinase 2 (LATS2), an important component of the Hippo signaling pathway, leading to increased Yes-associated protein 1 (YAP1) nuclear translocation, thereby enhancing PD-L1 transcription and impairing T cell proliferation in breast cancer [112].