FBXW7 and cancer: Further study indicates that CAFs contribute to cancer stemness, EMT, metastasis, and 5-FU/L-OHP resistance by directly transferring exosomes to cancer cells, which leads to a significant increase of miR-92a-3p and activation of Wnt/β-catenin pathway, hence inhibiting mitochondrial apoptosis by directly inhibiting F-box and WD repeat domain-containing 7 (FBXW7) and modulator of apoptosis 1 (MOAP1) [76].