In the current study, we sequenced more than 400 genes known to cause skin diseases, including 23 genes (TYR, OCA2, AP3B1, BLOC1S3, BLOC1S6, C10orf11, DTNBP1, FRMD7, GPR143, HPS1, HPS3, HPS4, HPS5, HPS6, LYST, MC1R, MITF, MLPH, MYO5A, RAB27A, SLC24A5, SLC45A2, TYRP1) associated with syndromic and non-syndromic albinism using targeted NGS in 18 patients, and identified 26 mutations in TYR and OCA2. After database retrieval and literature searches, two novel variants were identified. The gene discussed is HPS3; the disease is albinism.