ACE2 and hypertensive disorder: Advanced age (with comorbid hypertension) is a major risk factor for mortality in COVID-19 patients, thus it is uncertain whether this represents the burden of uncontrolled hypertension in the deceased population or occurred as a consequence of systemic inflammation and/or interference with angiotensin-converting enzyme 2 (ACE-2) enzymatic activity by SARS-CoV-2 [17].