INS and familial dilated cardiomyopathy: For example, in diabetes, autoantibodies can target insulin producing β-cells or insulin itself [15, 16], in dilated cardiomyopathy (DCM), which is the leading cause for heart failure and heart transplantation in younger adults, circulating autoantibodies mediate organ-specific tissue damage by targeting different epitopes on cardiac myocytes [17, 18].