The established PDX models comprised all major aggressive NHL subtypes, including DLBCL of the germinal center (GC) and non-GC immunophenotypes, double-hit DLBCL, transformed DLBCL, MCL, Burkitt lymphoma, PTCL, AITL, ALCL, ALK-positive, and ALCL, ALK-negative. The gene discussed is ALK; the disease is non-Hodgkin lymphoma.