In addition to changes in the composition of the TME, immunophenotypic alterations of PDX cells were observed as well, including low expression of SOX11 (and to a lesser extent of cyclin D1) in both PDX models of MCL; a lack of expression of cytotoxic granules and changed expression of lymphoma-associated markers (CD20, CD3) in several T-NHL PDX models. Here, SOX11 is linked to mantle cell lymphoma.