Among the 46 HC-SMGs, eight, namely, LYST (lysosomal trafficking regulator), DAPK1 (death-associated protein kinase 1), CR2 (complement receptor type 2), KIF16B (kinesin family member 16B), NPIPB15 (nuclear pore complex interacting protein family member B15), SYTL2 (synaptotagmin-like protein 2), ZNF91 (zinc finger protein 91), and KIAA0586 (encodes the protein TALPID3, a centrosomal protein that is essential for primary cilia formation), which were mutated in 14.9% (152/1015) of CRC patients, have not been reported in any of the above databases. The gene discussed is KIF16B; the disease is colorectal carcinoma.