The IL8-CXCR1/2 axis plays an important role in tumor growth, angiogenesis, metastasis, stemness, and recruitment of immune cells into the TME, by activation of downstream signaling cascades such as the PLC-PKC, PI3K-AKT, FAK/Src, MAPK-ERK, and RhoGTPase [24, 25]. The gene discussed is CXCL8; the disease is neoplasm.