We also observed increases in expression of regulators of triglyceride metabolism, including Angptl4 and Angptl827, the glycolytic/gluconeogenic enzyme AldoB, which is highly upregulated in models of β-cell mitochondrial dysfunction and in T2D islets28,29, as well as Nrf1, a key regulator of mitochondrial biogenesis (Figs. 5c, e, and S4d30). This evidence concerns the gene NRF1 and type 2 diabetes mellitus.