Interestingly, we found that NAD+ supplementation could effectively suppress Cd200r3 expression, while NMN supplementation could effectively suppress the expression of both Cd200r4 and Cd200r3. NAD+ intermediate and precursors, including NMN, NR, and NAM, have been shown to have anti-inflammatory effects in different animal models including aging, autoimmune encephalomyelitis, ischemia, Ataxia Telangiectasia and ZIKV infection2,3,55–58. This evidence concerns the gene STAC3 and Ataxia-telangiectasia.