The hemolysis detected in the lungs and the upregulation of genes involved in the production of NADPH and NADP+, including G6pdx, Pgd, and Nadk, suggest the occurrence of NADPH deficiency and compensative effects through the increased expression of genes involved in NADPH synthesis in the infected lungs. This evidence concerns the gene DECR1 and hyperinsulinemic hypoglycemia, familial, 4.