KMT2D and pachyonychia congenita: Among the known recurrently altered genes in PC, frameshift deletions of ARID1A, ATR, NBN, PTEN, ZMYM3, and SMARCA1 as well as nonsynonymous single-nucleotide variants (SNVs) of CHD1, KMT2D, TP53, and CDK12 were found (Table 1; Supplemental Table S1).