Among the 722 participants who hesitated to be vaccinated, when they were asked about factors affecting their vaccine willingness, a majority (482/722, 66.8%) of participants demonstrated concerns about a possible influence on ART, and 65% (469/722) had concerns about a possible influence on HIV disease status, that is the HIV disease would progress abnormally, including a rebound of viral load, or a decrease of absolute CD4+ T cell counts after COVID-19 vaccination. The gene discussed is CD4; the disease is COVID-19.