IL21 and systemic sclerosis: For example, GSVA demonstrated that the neutrophil signature was up-regulated in the majority of PSO and SSc patients, whereas the pDC, monocyte, monocyte/myeloid cell, and B cell signatures were increased in the majority of DLE and SSc patients; the T cell, IL-21 complex, inflammasome, and cell cycle signatures were increased in all diseases, except SSc.