USP53 (Ubiquitin specific peptidase 53) inhibits the initiation and progression of renal cell carcinoma by inhibiting activation of the nuclear factor κB (NF‐κB) pathway; it promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51‐AKT1 signaling [52, 53]. Here, AKT1 is linked to renal cell carcinoma.