PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In people with T2DM, PNPLA3 I148M or rs738409 polymorphism showed significant association with liver fibrosis independent of body mass index (BMI) [14] and with the risk of increased liver fat content (LFC) independent of serum lipids [15], but not with susceptibility of NAFLD [16].