mitfa-high cells (clusters 7,11) were enriched for pigmentation programs and melanoma-related terms, whereas mitfa-low cells (clusters 2,6,12) were enriched for essential metabolic pathways, including the 1C (THF) cycle, the TCA cycle and de novo purine biosynthesis (Fig. 4F), suggesting that regenerative McSCs have metabolic requirements distinct from those of melanoblasts. Here, MITF is linked to melanoma.