The topics discussed not only touched upon the role of RanBP2/Nup358 in cell function, viral infection and the innate immune response, but also the contribution of other nucleoporins to neurodegeneration diseases, the role of SUMO in regulating cell physiology, and the use of model systems to investigate interactions between airway epithelial cells and viral infection. The gene discussed is RANBP2; the disease is neurodegenerative disease.