Some studies reported that patients with hypoparathyroidism have an increased risk of fractures(54, 60) whereas others reported no increase in the risk of fracture(8) or a reduced risk of upper extremity fracture in postsurgical hypoparathyroidism.(6) In contrast with the results for BMD, both bone formation and resorption markers significantly increased during PTH replacement therapy. The gene discussed is PTH; the disease is hypoparathyroidism.