In the current study, we showed that LINC01606 acted as an oncogene and predicted poor survival in colon cancer, that genetic blockade of LINC01606 inhibited proliferation and stemness and induced apoptosis and ferroptosis, and that pharmacologic or genetic blockade of Wnt/β‐catenin signalling enhanced sensitivity to ferroptosis inducers in a model of cCSCs and in colon cancer cell lines. This evidence concerns the gene LINC01606 and malignant colon neoplasm.