Given that LINC01606 and SCD1 are essential in the maintenance of colon CSCs and that both participate in the activation of the Wnt/β‐catenin signalling, we sought to determine whether the LINC01606‐Wnt/β‐catenin signalling and colon CSCs were involved in Erastin‐ or RSL3‐induced ferroptosis in colon cancer cells. This evidence concerns the gene LINC01606 and malignant colon neoplasm.