SPRY4 and non-small cell lung carcinoma: Subsequently, the expression level of SPRY4 were increased enormously after pcDNA3.1-SPRY4 transfection in pLenti-miR-92a NSCLC cell lines, which indicated that pcDNA3.1-SPRY4 rescued the declined expression of SPRY4 caused by miR-92a overexpression successfully (Figure 6(a)).