As for the synergistic effects between miR-92a and miR-18a, we found that both miR-18a and miR-92a can target SPRY4 through the dual-luciferase reporter assay, so it proves that miR-18a and miR-92a may play tumor-promoting roles by targeting SPRY4 commonly. This evidence concerns the gene SPRY4 and neoplasm.