CCDC106 and ovarian cancer: To further assess this possibility, we evaluated the subcellular localization of CCDC106 in mutant p53 ovarian cancer cells (CAOV3 and SKOV3), in which CCDC106 is localized mainly in the nuclei, and in A2780 (wild-type p53) ovarian cancer cells that express CCDC106, which is primarily cytoplasmic.