Furthermore, Metacore analysis identified two TLR4‐dependent regulatory networks “I‐kB/AP‐1/IL‐1β/c‐Jun/MEK3 (MAP2K3)” and “c‐Fos/SOCS3/Oncostatin M/AP‐1/STAT3” as the predominant GRNs containing the highest numbers of DEGs and most outstanding significance in Cluster 0 (Figure 4C) and Cluster 1 (Figure 4D) monocytes, respectively, emphasizing the pivotal role of myeloid‐TLR4 in pro‐inflammatory monocytes polarization and infiltration during renal inflammation in anti‐GBM cGN. Here, SOCS3 is linked to childhood gender nonconformity.