Surprisingly, we discovered a novel anti‐inflammatory macrophage subtype (Nr4a1+ Ear2+) uniquely derived from macrophages with TLR4‐deficiency in anti‐GBM cGN kidney, demonstrating a novel role for TLR4/Nr4a1/Ear2 feedback axis in regulating macrophage‐mediated renal injury, which was further explored in this study. The gene discussed is TLR4; the disease is childhood gender nonconformity.