Furthermore, Metacore analysis identified two TLR4‐dependent regulatory networks “I‐kB/AP‐1/IL‐1β/c‐Jun/MEK3 (MAP2K3)” and “c‐Fos/SOCS3/Oncostatin M/AP‐1/STAT3” as the predominant GRNs containing the highest numbers of DEGs and most outstanding significance in Cluster 0 (Figure 4C) and Cluster 1 (Figure 4D) monocytes, respectively, emphasizing the pivotal role of myeloid‐TLR4 in pro‐inflammatory monocytes polarization and infiltration during renal inflammation in anti‐GBM cGN. This evidence concerns the gene OSM and childhood gender nonconformity.