To identify the cell‐type specific TFs and TF‐centered gene regulatory networks (GRNs), which responsible for macrophage heterogeneity in anti‐GBM cGN, we performed Single‐Cell rEgulatory Network Inference and Clustering (SCENIC)[16] in combination of Metacore pathway enrichment analysis.[27] In brief, Co‐expression modules between TFs and candidate target genes were firstly inferred, followed by identification of GRNs with direct binding to the activated TFs in every single cell using GENIE3 and RcisTarget. The gene discussed is TF; the disease is glioblastoma.