ADGRE1 and crescentic glomerulonephritis: In response to crescentic glomerulonephritis, seven transcriptionally distinct subpopulations of macrophages/monocytes were identified, including two groups of Cd14+ monocytes (Cluster 0, 1) and five clusters of Adgre1+ (F4/80) macrophages (Cluster 3, 4, 7, 8, 9) (Figure 2A).