Consistently, in vitro and in vivo (zebrafish larvae) data demonstrated a supportive role for FGFR4 in GBM cell migration, invasion, and adhesion, which was corroborated by gene expression analyses of our FGFR4-engineered glioma cell models and the TCGA-GBM data cohort. The gene discussed is FGFR4; the disease is glioma.