This translated well into regulated focal adhesion kinase (FAK) expression and phosphorylation levels, as well as talin protein expression in response to FGFR4 manipulation (Fig. 4E, Additional File 1: Figure S8B), resulting in significantly diminished adhesion potential to cell culture polystyrene in several GBM (Fig. 4F, Additional File 1: Figure S8C + D, left) and GSC (Additional File 1: Figure S8E) models upon FGFR4 blockade. This evidence concerns the gene PTK2 and glioblastoma.