FGFR4 and neoplasm: While both U251-MG sublines were tumorigenic in all animals tested (Fig. 6C), upregulation of wild-type FGFR4-388Gly in the endogenously FGFR4low U251-MG cells resulted in significantly enhanced tumor volumes (Fig. 6A) and shorter overall survival (Fig. 6B) as compared to GFP-control tumor-bearing mice.