These included retinoic acid receptor (RAR)/retinoid X receptor (RXR) signaling (e.g., NR0B2, NCOR2, VDR, RARRES1), androgen receptor signaling (e.g., PTEN, BRCA1, DSTN, RB1, FOXP1), cell proliferation and extracellular matrix (ECM) events including BPD-associated epithelial-mesenchymal transition (EMT) [48] (e.g., RB1, RBPJ, FOXP1, AVDR, CHRM5, COL21A1, VEPH1), and lung surfactant and glycosaminoglycan metabolism and alveolarization (e.g., CTSH, AGER, FOXP1, CAVIN2, SPOCK2, CHST14, HS6ST1, ARRB1, DSTN). The gene discussed is RB1; the disease is bronchopulmonary dysplasia.