Based on pathway enrichment analysis (Table 4), genes altered in BPD blood cells were mainly enriched in cell cycle regulation and arrest (e.g., PPP2CA, RBL2, CENPU, CCNY, CDK6) and pulmonary disorder and developmental disorders (e.g., AGER, ITGA6, CA4, BACH2, IGFBP2, BMPR2, SKI, DAB2). The gene discussed is IGFBP2; the disease is bronchopulmonary dysplasia.