Relying on Co-IP and ChIP experiments, Wu et al. showed that Ajuba, a multiple LIM domain-containing protein, can recruit CBP as well as Twist1 to form a protein complex at the Twist1-binding region and enhance the acetylation of histone H3 at the N-cadherin promoter in colorectal cancer cells [44]. This evidence concerns the gene TWIST1 and colorectal cancer.