HDAC1 and hepatocellular carcinoma: In addition, during TGF-β-initiated EMT, the effect of TGF-β on Snail2 expression is related to the inhibition of HDAC1 and HDAC3, which can suppress Snail2 transcription by downregulating the acetylation levels of H3K56 and H3K4 in hepatocellular carcinoma (HCC) cells [50].