Using quantitative reverse transcription PCR (RT-qPCR), the UCSC Genome Browser, and ChIP assays, the expression of lncRNA-ROR was found to be upregulated by the acetylation of histone H3K27 to induce EMT in retinoblastoma cells, and elevated H3K27 acetylation at the lncRNA-ROR promoter was associated with CBP [57]. This evidence concerns the gene LINC-ROR and retinoblastoma.