SNAI2 and lung adenocarcinoma: For example, based on ChIP-seq and ChIP analyses, Mishra et al. found that the transcription factor KLF10 occupying GC-rich sequences at the promoter of Snail2 could repress Snail2 transcription by recruiting HDAC1, which blocked the acetylation of H3K9 and H3K27 at the promoter of Snail2 in lung adenocarcinoma cells [49].