Molecular analysis of the recurrent tumor revealed the same genetic variants identified in primary resection, namely pathogenic mutations in PTPN11 and H3F3A. Whole Genome DNA methylation profiling using clinically validated brain tumor classification [11] was performed and the tumor classified as diffuse midline glioma H3 K27M mutant with calibrated score 0.8 and the copy number analysis using conumee package showed flat copy number profile and unmethylated MGMT promoter. This evidence concerns the gene PTPN11 and neoplasm.