There is one report of high grade brainstem glioma harboring both PTPN11 and H3F3A mutations, as well as one patient in a cohort of pediatric glioma with co-occurrence of H3 K27M mutations and other alterations in the MAPK pathway, including in BRAF and FGFR1 [7, 21]. Here, BRAF is linked to central nervous system cancer.