We conducted this study to investigate the genomic characteristics of breast tumors with HER2-zero (IHC 0), HER2-low (IHC 1+ or IHC 2+/FISH-negative), and HER2-positive (IHC 3+ or IHC 2+/FISH-positive) status, by retrospectively analyzing the molecular, clinical, and survival data from 523 Chinese women with breast cancer. Here, ERBB2 is linked to breast neoplasm.