Five KEGG categories, including pathways in cancer, B cell receptor signaling pathway, natural killer cell mediated cytotoxicity, leukocyte transendothelial migration, and T cell receptor signaling pathway, showed significantly differential enrichment in SGSM1 low expression phenotype (Fig. 4c); five KEGG categories, including neuroactive ligand receptor interaction, long term potentiation, calcium signaling pathway, gap junction, and phosphatidylinositol signaling system, showed significantly differential enrichment in SGSM1 high expression phenotype (Fig. 4d). Here, PPIB is linked to cancer.