ERBB2 and breast cancer: In oncology, for instance, in colorectal cancer [2], breast cancer [3], non-small cell lung cancer(NSCLS) prognostic [4], and predictive genes such as human epidermal growth factor receptor 2 (HER2), BRAF, KRAS are not only essential for early detection but also therapy selection, subgroup stratification, and controlled monitoring of the disease.