Compared to this group, protein levels of KRT20 and GATA3 were significantly enriched in non-invasive areas of CIS/T1HG and of pure TaHG/T1HG lesions (for KRT20: P < 0.001, for GATA3: P < 0.05) (Fig. 2). The gene discussed is GATA3; the disease is in situ carcinoma.