NECTIN4 and in situ carcinoma: A higher overall NECTIN4 positivity (92% and 96%) and membranous positivity (89% and 86%) was noted in HR NMIBC patients with multifocal CIS/T1HG and in patients with multifocal pure TaHG/T1HG lesions compared to patients exhibiting multifocal papillary HG tumors associated with LG lesions (overall NECTIN4 positivity: 67%, membranous positivity: 50%) (Table 3).