In contrast, a significantly lower NECTIN4 protein expression was noted in HG tumors from mixed-grade papillary lesions compared to both aforementioned HG tumor groups (overall positivity: 72%, membranous positivity: 69%, median H-score: 80, IQR H-score: 200–7; for both comparisons: P < 0.001) (Table 2 and Fig. 1). The gene discussed is NECTIN4; the disease is neoplasm.