Taken together, NECTIN4 protein expression was significantly enriched in luminal-like urothelial CIS/T1HG and pure papillary TaHG/T1HG tumor samples compared to normal urothelial NECTIN4 protein levels, while this was not true for papillary HG lesions from mixed-grade tumors, showing markedly lower NECTIN4 and luminal marker protein levels. This evidence concerns the gene NECTIN4 and neoplasm.