Ectopically expressing MYCN in mesenchymal Tet21N cells left transsulfuration via its rate-limiting enzyme CBS unchanged but induced SLC7A11, GSR, GCLC and thioredoxin reductase 1 (TXNRD1), the last one being significantly expressed in MYCN-amplified primary neuroblastomas (Extended Data Fig. 4b,c)37. Here, GCLC is linked to neuroblastoma.