[41] that IL-6 induced EMT-related gene expression, leading to EMT phenotypes in pancreatic cancer cell (AsPC-1, BxPC-3, and Panc-1 cells), in which mesenchymal-like markers including N-cadherin and vimentin were upregulated, and epithelial-like marker, E-cadherin were downregulated. This evidence concerns the gene IL6 and familial pancreatic carcinoma.