ESR1 and breast carcinoma: We observe that a high TIL (>p50) is not significantly correlated with a better prognosis (HR = 0.760, P = 0.212, LLR test) for patients with ER+HER2− breast cancer, also not when independently assessed in Luminal A (N = 273) and Luminal B (N = 193) breast cancer patients (Fig. S3).