ApoE exhibited robust protection against all four inducers with a potency (EC50 ≈ 7–13 nM) that exceeded that of the reference ferroptosis inhibitor, LPX (EC50 ≈ 11–50 nM), demonstrating that apoE selectively protects against CDI ferroptosis (Fig. 2D–G). The gene discussed is APOE; the disease is clostridium difficile infection.