After screening according to the three main parameters, the network indicated that these 26 genes play a key role in treatment of HLP, the node became larger and its color changed from yellow to red with the increased degree of the targets. The 26 targets were selected as the core targets as followed: AKT1, IL-6, TP53, TNF, VEGFA, JUN, MYC, CASP3, MAPK1, MAPK8, EGF, PTGS2, EGFR, MMP9, ESR1, CXCL8, CCND1, CAT, IL-1β, FN1, FOS, IL10, PTEN, CYCS, PPARG, and RELA (Table 2). The gene discussed is ESR1; the disease is hyperkeratosis lenticularis perstans.