At the same time, considering that HLP is often accompanied by fatty liver, oxidative stress increases the production of reactive oxygen species (ROS), leading to lipid peroxidation, and then leads to the production of TNF-α, IL-8 and other factors, which destroys the normal function of cells and leads to inflammation and apoptosis43,44. Here, CXCL8 is linked to hyperkeratosis lenticularis perstans.