CASP3 and hyperkeratosis lenticularis perstans: Therefore, IL-6, IL-1β, VEGFA and CASP3 were selected as candidate targets of BSTZC against HLP. In vivo experiment, compared with the control group, the contents of IL-6, IL-1β, VEGFA and CASP3 mRNA were significantly increased (P < 0.05, P < 0.01) in the model group.