HoxA5 along with HoxA9 is highly expressed in human ALL with MLL gene translocation and associated with poor prognosis of the disease51,52; Gsk3b and c-Myb enhance oncogenic potential of aging HSCs53,54, and Dnmt1 mediates silencing of genes marked by bivalent chromatin domains in leukemic progenitor cells55. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.