There are no studies on the mechanistic relationship between TREX2, ALKBH2, MC1R, and CRC. TREX2, a specific 3′-DNA exonuclease expressed in keratinocytes, plays a crucial role in promoting DNA damage repair, inducing cell apoptosis, arousing anti-cancer immunity, and suppressing skin carcinogenesis38. Here, TREX2 is linked to colorectal carcinoma.