However, our results demonstrate that even though baseline expression of the SARS-CoV-2 entry factor ACE2 is positively correlated with SARS-CoV-2 replication, and though ACE2 is an ISG, HRV-16 infection induces much more potent type I and III IFN responses than SARS-CoV-2 and heterologous infection of organotypic AEC cultures with HRV-16 three days prior to inoculation with SARS-CoV-2 markedly reduces replication of SARS-CoV-2. The gene discussed is IFNA1; the disease is infection.