In this study we directly compared type I and III IFN responses to SARS-CoV-2 and HRV-16 infection by primary organotypic bronchial AEC cultures from children and adults, and assessed the impact of exogenous treatment with recombinant IFNβ1 or IFNλ2 on SARS-CoV-2 replication as well as the impact of heterologous infection with HRV-16 prior to SARS-CoV-2. Here, IFNL2 is linked to infection.