We observed that IFNB1 and IFNL2 expression were significantly greater following HRV-16 than following infection with SARS-CoV-2 WA-01, SARS-CoV-2 Delta variant, or SARS-CoV-2 Omicron variant at equivalent MOIs (Supplementary Fig. 1A,B). Here, IFNB1 is linked to infection.