As compared to uninfected cultures, the relative increase in expression of IFNB1, INFL2, and CXCL10 following infection with HRV-16 was significantly greater than following infection with SARS-CoV-2, and the protein concentrations of type I and III IFN and the IFN stimulated chemokine CXCL10 in both cell lysates and supernatant were significantly greater in AEC cultures following infection with HRV-16 as compared to SARS-CoV-2. This evidence concerns the gene SGCG and infection.