For primary bronchial epithelial cultures wherein SARS-CoV-2 WA-01 and HRV-16 infection was compared in parallel, RNA harvested 96 h following infection was available from 22 donor cultures (n = 14 children, n = 8 adults) to allow measurement of IFNB1, IFNL2, and CXCL10 gene expression, and protein was available from cell lysate collected 96 h following infection from 20 donor cultures (n = 12 children, n = 8 adults) to allow for measurement of IFNβ1, IFNλ2 (IL-28A), and CXCL-10 protein levels. The gene discussed is IFNL2; the disease is infection.