IFNA1 and infection: The objectives of our study were to determine if heterogeneity in bronchial epithelial type I and III IFN responses to SARS-CoV-2 between individual pediatric and adult donors was associated with SARS-CoV-2 replication, to compare airway epithelial IFN responses between SARS-CoV-2 and human rhinovirus-A16 (HRV-16), and to determine the effects of HRV pre-infection or exogenous IFN treatment on SARS-CoV-2 replication in organotypic airway epithelial cell (AEC) cultures from children and adults.