The inducible Pkd2 KO cell model of PKD provides insights into the most acute changes after the loss of polycystin proteins and the early stages of disease progression26; observed phenotypical differences with the human ADPKD mature cysts cells suggests that further transformation may occur after PC2 loss and ADPKD cells from mature cysts behave differently. This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.