PKD1 and kidney disorder: For kidney disorders such as the Autosomal Dominant Polycystic Kidney Disease (ADPKD), where tubular morphology of the epithelium becomes disrupted and uncontrolled expansion of the cyst results, mutations in the polycystin genes (PKD1 and PKD2) and their protein products (PC1 and PC2) could also alter the shape and mechanical state of the kidney epithelium8,9.