To further confirm the role of NFATc3-K384 SUMOylation in tumor progression, AsPC-1 cells and PANC-1 cells with NFATc3 depletion were reconstituted with sgRNA-resistant wild-type (WT) NFATc3 (WT rNFATc3) or the deSUMOylation mimetic mutant NFATc3 K384R (rNFATc3 K384R) (Fig. 6a). The gene discussed is NFATC3; the disease is neoplasm.