The initiation of cancer metastasis involves in the augmented migratory and invasive capacities that are conferred by EMT on primary tumor cells.3 Upon extravasating into the parenchyma of distant organs, it seems that cancer cells undergo MET to support the outgrowth of micrometastases.4,61 We have clearly shown that OVOL1 suppresses EMT, cell migration, in vivo extravasation using a zebrafish embryo xenograft model, and early-stage metastatic colonization using a mouse xenograft model (Fig. 2a–f). Here, OVOL1 is linked to cancer.