Misu can affect the role of Myc, a well-known proto-oncogene, in tumor cell growth and proliferation.338 In addition, NSUN2, with high sequence homology to Misu, was overexpressed in almost all cancers.397 Xiang et al.398 conducted the first comprehensive analysis of m5C regulators in gastrointestinal cancer. Here, MYC is linked to cancer.