Recently, there have been many studies on m6A expression with regard to the prognosis of digestive system cancer.220–225 Li et al.226 discussed the expression pattern and prognostic significance of m6A-related genes in ESCC, reporting that YTHDF1, HNRNPC, ZC3H13, YTHDC2, and METTL14 are dysregulated in ESCC. The gene discussed is YTHDF1; the disease is esophageal squamous cell carcinoma.