METTL14 and colorectal carcinoma: YTHDC1 preferentially recognized m6A residues on XIST that were required for XIST to function.101,184 In addition, METTL14 inhibits the growth and metastasis of CRC by downregulating the carcinogenic lncRNA XIST.185 Hu and Ji186 found that METTL14-mediated m6A modification results in LINC01320 upregulation.