Further research revealed that METTL3 might inhibit RCC cell proliferation, migration, and invasion through the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway and play a tumor suppressor role.276 Another major m6A methyltransferase, METTL14, also inhibits RCC progression.277 Interestingly, however, WATP is upregulated in RCC and upregulates CDK2 expression by stabilizing its transcripts, promoting RCC tumorigenesis. This evidence concerns the gene METTL3 and renal cell carcinoma.