DKC1 and hepatocellular carcinoma: Loss of rRNA m1acp3Ψ modification is a hallmark of cancer.497 Furthermore, DKC1 enhances CRC angiogenesis by directly activating hypoxia-inducible factor-1α transcription, promoting CRC cell metastasis.498 In HCC, DKC1 expression is similarly upregulated and exerts a tumor-promoting effect.