Genetic alterations in m6A regulators in ccRCC were identified for the first time, and a significant association between these alterations and worse clinical features was found.275 Unlike other cancers, this study showed that METTL3 was upregulated in RCC, and METTL3-negative expression was associated with larger tumor size (P = 0.010) and higher histological grade (P = 0.021). The gene discussed is METTL3; the disease is renal cell carcinoma.