In contrast, NSUN1 forms an active, 5-AZA-insensitive chromatin structure mainly with BRD4 and RNA polymerase II.429 High p120 (NSUN1) expression in PCa was related to increased tumor aggressiveness and poor prognosis.430 Similarly, NSUN2 was upregulated in HNSCC, and high NSUN2 expression was closely associated with poor clinical outcomes. The gene discussed is NOP2; the disease is head and neck squamous cell carcinoma.