Also considered an FTO inhibitor, R-2HG exerts a tumor suppressor effect in leukemia and glioma by targeting FTO/m6A/MYC/CEBPA signaling.308 In addition, FB23-2, rhein, etc., are currently known inhibitors of FTO.524,525 In chemoradiotherapy, resistance to therapy is an unresolved bottleneck and challenge in cancer treatment. The gene discussed is FTO; the disease is glioma.