In another study, METTL3 may positively regulate the processing of pri-miR221/222 into mature miRNA by interacting with DGCR8, thereby playing an oncogenic role in BLC.264 Of course, other studies showed that METTL14 and FTO are under-expressed in BLC and mainly play a tumor suppressor role.58,265. This evidence concerns the gene FTO and neoplasm.