METTL3 and neoplasm: Further research revealed that METTL3 might inhibit RCC cell proliferation, migration, and invasion through the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway and play a tumor suppressor role.276 Another major m6A methyltransferase, METTL14, also inhibits RCC progression.277 Interestingly, however, WATP is upregulated in RCC and upregulates CDK2 expression by stabilizing its transcripts, promoting RCC tumorigenesis.