DKC1 and neoplasm: Particularly in BRC, low dyskerin expression results in rRNA pseudouridylation and a reduction in the RNA component of telomerase.506 In addition, p53 is a well-known tumor suppressor, and p53 function is also reduced in the presence of low keratin levels, contributing to the tumor phenotype.507 At first glance, the finding that DKC1 is overexpressed in common carcinomas seems contradictory, as keratin-inactivating mutations in DC confer increased tumor susceptibility.