Mechanistically, NSUN2 methylated the 3′-UTR of CDKN1C (p57Kip2) mRNA, which led to p57Kip2 downregulation.404 Another study on NSUN2 and GC revealed that high NSUN2 expression was closely related to poor prognosis in GC patients. The gene discussed is NSUN2; the disease is gastric cancer.