ALKBH5 and cancer: In most cases, these regulatory proteins are mainly upregulated in lung cancer and play a cancer-promoting role.249–254 ALKBH5 increases FOXM1 expression by downregulating m6A modification on FOXM1 mRNA, ultimately promoting LUAD cell proliferation and invasion in an intermittent hypoxic environment.255 However, Jin et al.256 indicated that ALKBH5 expression is reduced in NSCLC, and high ALKBH5 expression predicts a good clinical prognosis.