CXCL10 and infection: Interestingly, this strong network of CXCL10 specific gene signature was no longer restricted to AMs later in infection as different macrophage subsets continuously differentiate, evident in high IL7R expression by developing lung macrophages50 (CXCL10+ and AM) at all timepoints (Fig. 1g, 3d, Extended data Fig. 12d).