In line with our findings, CD14hiCD16hi cells and AMs enriched with viral RNA in autopsy lungs of COVID-19 patients7,20 also had distinct transcriptomes which were largely recapitulated in what we construe as CXCL10-associated genes (CXCL11, CCL18, CCL8, ISG15, CD83). Here, ISG15 is linked to COVID-19.