Indeed, the cellular interactions in high-burden granulomas revealed both specific signaling molecules (e.g., FGF1 from type 1 pneumocytes, PDGFB from endothelial cells, ANGPTL4 from plasma and mast cells, among others) and broad pathways that reflected fibrosis, metabolic remodeling, and angiogenesis. Here, FGF1 is linked to Granuloma.