In contrast, low-burden granulomas exhibited cell-cell interactions consistent with type 1 immune responses (CCL3, CXCL9/10/11, IL18) and Th17 chemoattraction (CXCL16, CCL20), co-stimulatory molecules important in immune activation (CD40LG, CD48, CD80, CD86), and those involved in lymphocyte adhesion (CD58) (Figure 6I) (Li et al., 2013; Lim et al., 2008; Touzot et al., 2014). This evidence concerns the gene CD40LG and Granuloma.