TGFB1 and Granuloma: This interpretation was further supported by enrichment of pathways such as TGFβ, WNT, and FGF signaling, as well as organogenesis, epithelial/endothelial proliferation, and tissue-remodeling processes (Figure S6F); is consistent with prior descriptions of angiogenesis and fibrosis in human granulomas (McCaffrey et al., 2022; Polena et al., 2016); and supports the targeting of vasculature as a therapeutic direction for tuberculosis (Datta et al., 2015; Oehlers et al., 2015).