Fetal macrosomia revealed during pregnancy should needs to be differentiated from other associated disease such as Sotos syndrome, Beckwith-Wiedemann syndrome, Sotos syndrome, and Pallister-Killian syndrome.[11,12] In addition, it has been proposed that elevated maternal plasma alpha-fetoprotein and increased NT may be prenatal markers of SGBS1.[13,14] However, in our case, the fetus displayed normal NT and maternal plasma alpha-fetoprotein. This evidence concerns the gene AFP and tetrasomy 12p.