The most severe form is the X-linked CNM (XL-CNM), which is caused by LoF mutations in the myotubularin MTM1 gene, while three different genes, DMN2, BIN1, and RYR1, have been identified to cause an autosomal dominant CNM (AD-CNM) form[99]. This evidence concerns the gene RYR1 and centronuclear myopathy.