Patients with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels ≥5 times the upper limit of normality (ULN), severe renal failure (defined by a glomerular filtration rate [GFR] <30 ml/min), undergoing hemodialysis or peritoneal dialysis, pregnant women, and those with signs of multiorgan failure were also excluded from the national protocol [5]. This evidence concerns the gene GPT and kidney failure.