The Indian population tends to be more insulin-resistant compared to their white counterparts, attributable to a rapidly increasing body mass index (BMI) and central obesity.3 Insulin resistance is defined as decreased or impaired sensitivity to the effects of insulin on the target organs resulting in impaired glucose utilization.4 Due to the reduced response of the peripheral tissues to normal physiological levels of insulin, compensatory hyperinsulinemia occurs. The gene discussed is INS; the disease is hyperinsulinism.