In the CRISPS2 study, a large normotensive group (n=1344; mean BMI 23.5; HOMA-IR 1.0) was followed for a mean of 6.4 years; 16% (n=84 out of 1344) subsequently developed HT, and the observed values in this incident hypertensive group (mean BMI 25 kg/m2, TGL 124 mg/dL, HOMA-IR 1.3, fasting plasma insulin 5.4 mIU/L) were statistically significant.23 Our results, when comparing hypertensive to normotensive subjects, were closely in line with the CRISPS2 study with regard to fasting insulin level, HOMA-IR, and TGL. The gene discussed is INS; the disease is hematocrit.