In a study of myocardial ischemia-reperfusion injury, researchers found that Puerarin can reduce the expression of inflammatory cytokines IL-6, IL-1β, and TNF-α through AMPK/Akt/GSK-3β /Nrf2 signaling pathway to prevent myocardial ischemia-reperfusion injury [43]. Here, IL6 is linked to myocardial ischemia.