Our finding on the interweaving associations between radiomic features and pathohistological and genetic profiles, as well as findings from several other publications (regarding prediction of lung cancer histopathology [25], EGFR and ALK mutations [26, 27], and prognosis among ALK-positive patients [28] using radiomic features), altogether confirm the presence of a connection between the macro-level imaging information and micro-level biology. This evidence concerns the gene ALK and lung cancer.